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master's thesis
Određivanje antioksidativnog karaktera odabranih boroničnih kiselina cuprac metodom
diplomski rad
2017. urn:nbn:hr:167:532008
Grubišić, Ena
University of Split
Faculty of Chemistry and Technology
Division of Chemistry

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Grubišić, E. (2017). Određivanje antioksidativnog karaktera odabranih boroničnih kiselina cuprac metodom : diplomski rad (Master's thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:532008

Grubišić, Ena. "Određivanje antioksidativnog karaktera odabranih boroničnih kiselina cuprac metodom : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:167:532008

Grubišić, Ena. "Određivanje antioksidativnog karaktera odabranih boroničnih kiselina cuprac metodom : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2017. https://urn.nsk.hr/urn:nbn:hr:167:532008

Grubišić, E. (2017). 'Određivanje antioksidativnog karaktera odabranih boroničnih kiselina cuprac metodom : diplomski rad', Master's thesis, University of Split, Faculty of Chemistry and Technology, accessed 19 December 2024, https://urn.nsk.hr/urn:nbn:hr:167:532008

Grubišić E. Određivanje antioksidativnog karaktera odabranih boroničnih kiselina cuprac metodom : diplomski rad [Master's thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2017 [cited 2024 December 19] Available at: https://urn.nsk.hr/urn:nbn:hr:167:532008

E. Grubišić, "Određivanje antioksidativnog karaktera odabranih boroničnih kiselina cuprac metodom : diplomski rad", Master's thesis, University of Split, Faculty of Chemistry and Technology, Split, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:167:532008

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Metadata
TitleOdređivanje antioksidativnog karaktera odabranih boroničnih kiselina cuprac metodom : diplomski rad
Title (english)Determination of antioxidant character of selected boronic acids using cuprac method : diploma thesis
AuthorEna Grubišić
MentorMladen Miloš (mentor)
Committee memberIvica Blažević (predsjednik povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
Defense date and country2017, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Oksidativni stres je štetan proces koji može biti važan posrednik oštećenja staničnih struktura i može uzrokovati razna stanja bolesti i starenja. Antioksidacijska mjerenja se provode za dijagnozu i liječenje bolesti povezanih s antioksidativnim stresom, za usporedbu hrane s obzirom na sadržaj antioksidansa i za kontrolu varijacija između proizvoda. Jedinstvena i svestrana reaktivnost i stabilnost boroničnih kiselina dovele su do upotrebe u brojnim područjima. Nekoliko jedinstvenih svojstava boroničnih kiselina, poput niske toksičnosti, čini ih prikladnim za biomedicinske primjene. U ovom radu su istraživani spojevi iz klase boroničnih kiselina i osnovni zadatak je bio testirati navedene spojeve kao potencijalne antioksidanse. Za određivanje antioksidativnog kapaciteta koristila se CUPRAC metoda koja je temeljena na redukciji Cu(II) kompleksa u prisutnosti antioksidansa. Mjerenja su se vršila na metil boroničnoj kiselini, fenil boroničnoj kiselini i 2,4,6-trifluor fenil boroničnoj kiselini. Metil boronična kiselina može biti antioksidans koji sporo reagira, ali jer ni nakon 60 minuta nije pokazao promjenu boje može se zaključiti da ne posjeduje primjetan antioksidativni potencijal. Iz rezultata može se zaključiti da 2,4,6-trifluor fenil boronična kiselina ima veći antioksidativni kapacitet od fenil boronične kiseline.
Abstract (english)
Oxidative stress is a damaging process that can be an important mediator of damage to cell structures and can cause various disease states and ageing. Antioxidative measurements are conducted for the diagnosis and the treatment of diseases associated with antioxidative stress, for comparison of foods with respect to their antioxidant content and for controling variations between products. Unique and versatile reactivity and stability of boronic acids have led to the uses in many areas. Several unique properties of boronic acids, such as low toxicity, make them suitable for biomedical applications. This paper investigated the compounds of the class of boronic acids and the main task was to test these compounds as potential antioxidants. To determine the antioxidant capacity, a CUPRAC method was used which was based on the reduction of Cu (II) complexes in the presence of antioxidants. Measurements were performed on methyl boronic acid, phenyl boronic acid and 2,4,6-trifluorophenyl boronic acid. Methyl boronic acid can be a slow- reacting antioxidant, but since no change in color has occurred after 60 minutes it can be concluded that it does not have a noticeable antioxidative potential. From the results it can be concluded that 2,4,6- trifluorophenyl boronic acid has a higher antioxidative capacity than phenyl boronic acid.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:532008
ProjectNumber: IP-2014-09-6897
Title: Istraživanje bioaktivnih spojeva iz dalmatinskogbilja: njihov antioksidacijski karakter i utjecaj na enzimsku inhibiciju i zdravlje
Acronym: BioActCom
Leader: Mladen Miloš
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Chemistry; specializations in: Environmental Protection, Organic Chemistry and Biochemistry
Course: Organic Chemistry and Biochemistry
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Public noteKljučne riječi doradio knjižničar/ Key words are revised by the librarian
Created on2018-05-02 11:21:59