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master's thesis
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Safety and efficacy of opioid analgesic recommended for pain and paliative care by the World health organization
diploma thesis
Ivana Utrobičić (2017)
University of Split
Faculty of Chemistry and Technology
Library
University of Split
School of Medicine
Metadata
TitleAnaliza djelotvornosti i sigurnosti opioidnih analgetika u skupini lijekova za bol i palijativnu skrb za djecu na listi osnovnih lijekova Svjetske zdravstvene organizacije : diplomski rad
AuthorIvana Utrobičić
Mentor(s)Livia Puljak (thesis advisor)
Abstract
Uvod: Bol je neugodan osjet i emocionalno iskustvo povezano sa stvarnim ili potencijalnim oštećenjem tkiva. Cilj: Cilj ovog istraživanja je bio pronaći i analizirati dokaze o djelotvornosti i sigurnosti lijekova koje Svjetska zdravstvena organizacija (SZO) preporučuje na Listi osnovnih lijekova (engl. Essential Medicines List, EML), te time potvrditi jeli njihovo uvrštavanje na spomenutu listu opravdano. Metode: Pretražene su četiri bibliografske baze podataka i analizirana je kvaliteta sustavnih pregleda. Rezultati: U istraživanje je uključeno 13 sustavnih pregleda. U tim sustavnim pregledima najviše je analizirana djelotvornost i sigurnost morfina. Većina njih je zaključila da je morfin jednako djelotvoran ili lošiji od aktivnih komparatora. Jedan sustavni pregled je zaključio da rutinska primjena morfina nije opravdana kod novorođenčadi koja koriste umjetno disanje. Jedan sustavni pregled zaključuje da upotreba ketamina nije dovoljna za sprječavanje razvoja ovisnosti o opioidima. Samo jedan sustavni pregled je ispitivao djelotvornost i sigurnost oksikodona i tu nema zaključaka zasebno za oksikodon. Sustavni pregled u kojem je analiziran hidromorfon zaključuje kako je taj lijek jednak morfinu ili bolji za akutnu bol. Niti jedan sustavni pregled nije analizirao uporabu tih lijekova u palijativnoj skrbi djece. Zaključak: Upitna je opravdanost uvrštavanja tih lijekova na SZO EML za liječenje boli u djece. Svi uključeni radovi ukazuju na potrebu za daljnjim kliničkim pokusima o djelotvornosti i sigurnosti tih lijekova za liječenje boli, a nema ni dokaza iz sustavnih pregleda o tim lijekovima za palijativnu skrb u djece.
Keywordsdrugs analgesics morphine hydromorphone oxycodone pain World Health Organization Essential Medicines List(EML) systematic literature retrieval randomized controlled trials (RCT) search engines OVID Embase MEDLINE (PubMed) Cochrane library Cochrane Database of Systematic Reviews(CDSR) DARE (Database of Abstracts of Reviews of Effects)
Parallel title (English)Safety and efficacy of opioid analgesic recommended for pain and paliative care by the World health organization : diploma thesis
Committee MembersDamir Sapunar (committee chairperson)
Ivica Grković (committee member)
Livia Puljak (committee member)
GranterUniversity of Split
Faculty of Chemistry and Technology
Library
GranterUniversity of Split
School of Medicine
PlaceSplit
PlaceSplit
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Pharmacy
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmePharmacy
Academic title abbreviationmag. pharm.
Genremaster's thesis
Language Croatian
Defense date2017-10-06
Parallel abstract (English)
Background: Pain is an unpleasant sensation and an emotional experience associated with actual or potential tissue damage. Aim: The aim of this study was to find evidence from relevant systematic reviews and analyze the effectiveness and safety evidence of the opioid analgesics listed on the WHO EML for pain and palliative care in children, and therefore to analyze whether their inclusion on the WHO EML is justified. Methods: Four databases were searched and the quality of reporting was analyzed. Results: Thirteen systematic reviews were included in the study. The effectiveness and safety of morphine was mostly analyzed in those systematic reviews. Most of them concluded that morphine is equally effective or worse than active comparators. One systematic review concluded that routine use of morphine is not justified in the infants who are using artificial respiration. One of the systematic reviews concludes that the use of ketamine is not sufficient for the prevention of opioid dependence. Only one of the systematic reviews studied the effectiveness and safety of oxycodone and there weren’t conclusions solely for oxycodone. The systematic review which analyzed hydromorphone concludes that it is equal or better compared to morphine in acute pain. None of the systematic reviews alalyzed the use of these medicines in palliative care of children.
Parallel keywords (Croatian)lijekovi analgetici morfin hidromorfon oksikodon bol palijativna skrb za djecu Svjetska zdravstvena organizacija Lista osnovnih lijekova sustavno pretraživanje literature randomizirani kontrolirani pokusi (RCT) pretraživači OVID Embase MEDLINE (PubMed) Cochrane knjižnica Cochrane Database of Systematic Reviews(CDSR) DARE (Database of Abstracts of Reviews of Effects)
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
NoteKljučne riječi doradio knjižničar/ Key words are revised by the librarian
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:167:805253