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undergraduate thesis
Inhibicijsko djelovanje α- i β-jonona na aktivnost acetilkolinesteraze
završni rad
2016. urn:nbn:hr:167:210483
Grbelja, Iva
University of Split
Faculty of Chemistry and Technology
Division of Chemistry

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Grbelja, I. (2016). Inhibicijsko djelovanje α- i β-jonona na aktivnost acetilkolinesteraze : završni rad (Undergraduate thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:210483

Grbelja, Iva. "Inhibicijsko djelovanje α- i β-jonona na aktivnost acetilkolinesteraze : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:167:210483

Grbelja, Iva. "Inhibicijsko djelovanje α- i β-jonona na aktivnost acetilkolinesteraze : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:167:210483

Grbelja, I. (2016). 'Inhibicijsko djelovanje α- i β-jonona na aktivnost acetilkolinesteraze : završni rad', Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, accessed 19 November 2024, https://urn.nsk.hr/urn:nbn:hr:167:210483

Grbelja I. Inhibicijsko djelovanje α- i β-jonona na aktivnost acetilkolinesteraze : završni rad [Undergraduate thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2016 [cited 2024 November 19] Available at: https://urn.nsk.hr/urn:nbn:hr:167:210483

I. Grbelja, "Inhibicijsko djelovanje α- i β-jonona na aktivnost acetilkolinesteraze : završni rad", Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, Split, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:167:210483

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Metadata
TitleInhibicijsko djelovanje α- i β-jonona na aktivnost acetilkolinesteraze : završni rad
Title (english)Inhibitory effect of α- i β-ionone on the activity of acetylcholinesterase : bachelor thesis
AuthorIva Grbelja
MentorFranko Burčul (mentor)
Committee memberFranko Burčul (predsjednik povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
Defense date and country2016-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Enzimi su biokatalizatori koji kataliziraju reakcije na način da stabiliziraju prijelazno stanje, najviše energijsko stanje na reakcijskom putu. Enzimi su visoko specifični i po reakcijama koje kataliziraju i po supstratu. Acetilkolinesteraza (AChE) je enzim iz skupine hidrolaza. Njezina je fiziološka uloga hidroliza neuroprijenosnika acetilkolina (ACh) tijekom prijenosa živčanih impulsa. Nalazi se u sinapsama te živčanim i glija stanicama ljudskog mozga. Alzheimerova bolest se manifestira kao gubitak pamćenja, "izgubljenost" u vremenu i prostoru, nemogućnost samostalnog života, što dovodi do potpune ovisnosti o stalnoj skrbi i njezi druge osobe. Liječenje je ograničeno samo na ublažavanje pojedinih popratnih simptoma, a smatra se da inhibicija acetilkolinesteraze ima ključnu ulogu u ublažavanju simptoma Alzheimerove demencije. U ovom radu α- i β-jonon su ispitivani kao inhibitori acetilkolinesteraze. Uočeno je da se povećanjem koncentracije α- i β-jonona povećava i postotak inhibicije AchE-a. Najveća vrijednost inhibicije za α-jonon postignuta je pri koncentraciji od 90,9 μg mL-1 i iznosi 17,1 %, dok je za β-jonon pri koncentraciji od 113,6 μg mL-1 te iznosi 24,17 %.
Abstract (english)
Enzymes are biocatalysts that catalyse reactions by stabilizing the transition state, the highest energy state in the reaction pathway. Enzymes are highly specific by the reactions they catalysed, as well as their substrate. Acetylcholinesterase (AChE) is an enzyme from the hydrolases group. Its physiological role is the hydrolysis of the neurotransmitter acetylcholine (ACh) during transmission of nerve impulses. It is found in the synapses and the nerve and glial cells of the human brain. Alzheimer’s disease is manifested as forgetfulness, disorientation in time and space, the inability of independent living, which leads to total dependence on a constant concern and care from others. Treatment is limited to the alleviation of some accompanying symptoms. Inhibition of acetylcholinesterase plays a key role in alleviating the symptoms of Alzheimer’s dementia. In this study α- and β-ionone were tested for their inhibition ability on acetylcholinesterase. It has been observed that increasing the concentration of α- and β-ionone, the percentage of inhibition also increases. The maximum inhibitory activity for α-ionone of 17,1 % was reached at 90,9 μg mL-1while β-ionone reached 24,17 % at a concentration of 113,6 μg mL-1.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:210483
ProjectNumber: 6897
Title: Istraživanje bioaktivnih spojeva iz dalmatinskog bilja: njihov antioksidacijski karakter i utjecaj na enzimsku inhibiciju i zdravlje
Acronym: BioActCom
Leader: Mladen Miloš
Jurisdiction: Croatia
Funder: HRZZ
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Public noteKljučne riječi doradio knjižničar / Key words have been revised by the librarian
Created on2017-06-14 10:56:17