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master's thesis
Anksiolitici - biološki učinak temeljen na strukturi i interakcije s drugim lijekovima
diplomski rad
2016. urn:nbn:hr:167:476144
Prelčec, Kristina
University of Split
Faculty of Chemistry and Technology
Division of Chemistry

Cite this document

Prelčec, K. (2016). Anksiolitici - biološki učinak temeljen na strukturi i interakcije s drugim lijekovima : diplomski rad (Master's thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:476144

Prelčec, Kristina. "Anksiolitici - biološki učinak temeljen na strukturi i interakcije s drugim lijekovima : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:167:476144

Prelčec, Kristina. "Anksiolitici - biološki učinak temeljen na strukturi i interakcije s drugim lijekovima : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:167:476144

Prelčec, K. (2016). 'Anksiolitici - biološki učinak temeljen na strukturi i interakcije s drugim lijekovima : diplomski rad', Master's thesis, University of Split, Faculty of Chemistry and Technology, accessed 10 December 2024, https://urn.nsk.hr/urn:nbn:hr:167:476144

Prelčec K. Anksiolitici - biološki učinak temeljen na strukturi i interakcije s drugim lijekovima : diplomski rad [Master's thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2016 [cited 2024 December 10] Available at: https://urn.nsk.hr/urn:nbn:hr:167:476144

K. Prelčec, "Anksiolitici - biološki učinak temeljen na strukturi i interakcije s drugim lijekovima : diplomski rad", Master's thesis, University of Split, Faculty of Chemistry and Technology, Split, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:167:476144

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Metadata
TitleAnksiolitici - biološki učinak temeljen na strukturi i interakcije s drugim lijekovima : diplomski rad
Title (english)Anxiolytics - biological effect based on the structure and interactions with other drugs : master's thesis
AuthorKristina Prelčec
MentorMarica Medić-Šarić (mentor)
Committee memberDarko Modun (predsjednik povjerenstva)
Committee memberIvana Mudnić (član povjerenstva)
Committee memberMarica Medić-Šarić (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
Defense date and country2016-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Abstract
Cilj ovog diplomskog rada bio je prikazati utjecaj strukturnih promjena na molekuli benzodiazepina na njihov biološki učinak te prikazati interakcije velike kliničke značajnosti koje se mogu javiti istovremenom primjenom s drugim lijekovima. Svi benzodiazepini imaju osnovnu strukturu čijom se promjenom mijenjaju i farmakološka svojstva. Prikazana je promjena benzodiazepina, prema ATC klasifikaciji skupina N05B – alprazolam, bromazepam, diazepam, lorazepam i oksazepam, kroz reakcije I. i II. faze biotransformacije te su pomoću besplatnog javnodostupnog pretraživača interakcija prikazane interakcije velikog kliničkog značaja.Alprazolam, bromazepam i diazepam, kao pripadnici skupine srednje dugodjelujućih i dugodjelujućih benzodiazepina, reakcijama biotransformacije prelaze u aktivne oblike. Tako, α-hidroksialprazolam i nordiazepam (oksazepam) odnosno temazepam pojačavaju i produljavaju učinke alprazolama i diazepama. Međutim, bromazepam pripada skupini srednje dugodjelujućih benzodiazepina i reakcijom hidroksilacije prelazi u α-hidroksibromazepam, nastali aktivni metabolit značajno ne pridonosi produljenju učinka bromazepama. Nadalje, lorazepam i oksazepam podliježu samo glukuronidaciji, reakciji II. faze kojom nastaju glukuronid lorazepama i glukuronid oksazepama koji nemaju farmakološki učinak. Na benzodiazepinima nikada ne nastaju toksični semikinoni niti kinoni. Alprazolam, bromazepam i diazepam stvaraju aktivne metabolite koji potencijalno mogu stupiti u farmakokinetske interakcije posredovane enzimima CYP dok lorazepam i oksazepam stupaju u farmakodinamske jer se ne metaboliziraju putem enzima CYP.
Abstract (english)
The objective of this study was to show how the change in the structure of benzodiazepines affects the biological effect of benzodiazepines and clinically significant drug interactions which can appear while simultaniously consuming benzodiazepines and other drugs. All benzodiazepines have a basic structure and by the change of that structure are also changed the pharmacological properties. Benzodiazepine with ATC code N05B – alprazolam, bromazepam, diazepam, lorazepam and oxazepam were observed through the reactions of phase I and phase II of biotransformation and there are shown most signifficant drug interactions with the help od free public interaction checker. Alprazolam, bromazepam and diazepam are a part of medium-long acting and long-acting group of benzodiazepines and through the reactions of biotransformation they transform into active form. α-hydroxyalprazolam, nordiazepam (oxazepam) and temazepam amplify and extend the effects of alprazolam and diazepam. However, bromazepam is a part of medium-long acting group and through biotransformation converts into α-hydroxybromazepam which has no significant effect on the length of pharmacological activity of bromazepam. Furthermore, lorazepam and oxazepam have no active form since they only undergo glucuronidation. Benzodiazepines do not make toxic semiquinones neither quinones. Alprazolam, bromazepam and diazepam transform into active metabolites which can enter pharmacokinetic interactions mediated with enzyme CYP while lorazepam and oxazepam do not undergo biotransformation with enzyme CYP and therfore enter farmacodinamic interactions
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:476144
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-11-23 11:49:28