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undergraduate thesis
Gastrointestinalna stabilnost izotiocijanata iz mikrovalnog ekstrakta biljke dragoljub (Tropaeolum majus L.) nakon dvofaznog simuliranog modela probave
završni rad
2019. urn:nbn:hr:167:166415
Antolović, Nikolina
University of Split
Faculty of Chemistry and Technology
Division of Engineering and Chemistry

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Antolović, N. (2019). Gastrointestinalna stabilnost izotiocijanata iz mikrovalnog ekstrakta biljke dragoljub (Tropaeolum majus L.) nakon dvofaznog simuliranog modela probave : završni rad (Undergraduate thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:166415

Antolović, Nikolina. "Gastrointestinalna stabilnost izotiocijanata iz mikrovalnog ekstrakta biljke dragoljub (Tropaeolum majus L.) nakon dvofaznog simuliranog modela probave : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:167:166415

Antolović, Nikolina. "Gastrointestinalna stabilnost izotiocijanata iz mikrovalnog ekstrakta biljke dragoljub (Tropaeolum majus L.) nakon dvofaznog simuliranog modela probave : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:167:166415

Antolović, N. (2019). 'Gastrointestinalna stabilnost izotiocijanata iz mikrovalnog ekstrakta biljke dragoljub (Tropaeolum majus L.) nakon dvofaznog simuliranog modela probave : završni rad', Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, accessed 22 January 2025, https://urn.nsk.hr/urn:nbn:hr:167:166415

Antolović N. Gastrointestinalna stabilnost izotiocijanata iz mikrovalnog ekstrakta biljke dragoljub (Tropaeolum majus L.) nakon dvofaznog simuliranog modela probave : završni rad [Undergraduate thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2019 [cited 2025 January 22] Available at: https://urn.nsk.hr/urn:nbn:hr:167:166415

N. Antolović, "Gastrointestinalna stabilnost izotiocijanata iz mikrovalnog ekstrakta biljke dragoljub (Tropaeolum majus L.) nakon dvofaznog simuliranog modela probave : završni rad", Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:167:166415

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Metadata
TitleGastrointestinalna stabilnost izotiocijanata iz mikrovalnog ekstrakta biljke dragoljub (Tropaeolum majus L.) nakon dvofaznog simuliranog modela probave : završni rad
Title (english)Gastrointestinal stability of isothiocyanates from nasturtium (Tropaeolum majus L.) microwave extract after simulated two-phase digestion process : bachelor thesis
AuthorNikolina Antolović
MentorTea Bilušić (mentor)
MBZ: 238765
Committee memberFranko Burčul (predsjednik povjerenstva)
Committee memberDanijela Skroza (član povjerenstva)
Committee memberTea Bilušić (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Engineering and Chemistry)
Split
Defense date and country2019-10-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
Dragoljub (Tropaeolum majus L.) je jednogodišnja zeljasta biljka koja je bogat izvor vitamina C, ali i brojnih drugih biološki aktivnih komponenti za koje je dokazano da imaju ljekovita svojstva. Pripada maloj porodici Tropaeolaceae koja spada u red Capparales. Posebno znaĉajna skupina biološki aktivnih spojeva koji se mogu naći u dragoljubu su glukozinolati. Oni su kemijski stabilni i biološki neaktivni spojevi, dok njihovi razgradni produkti mogu imati razliĉite pozitivne uĉinke na organizam. U ovom radu analizirano je eteriĉno ulje koje je izolirano iz sjemenki dragoljuba postupkom mikrovalne ekstrakcije. Identifikacija spojeva u eteriĉnom ulju koji nastaju hidrolizom glukozinolata provedena je GC-MS tehnikom. Rezultati ove analize pokazali su prisutnost dva spoja, benzil nitrila u maloj i benzil izotiocijanata u prevladavajućoj koliĉini. Cilj je bio ispitati gastrointestinalnu stabilnost benzil izotiocijanata u dvofazno simuliranom modelu probave. Biodostupnost nekog spoja oznaĉava koliĉinu tog spoja koja se oslobaĊa u probavnom traktu i postaje dostupna za apsorpciju. Nakon provedenog modela in vitro probave, analiza uraĊena GC-FID tehnikom pokazala je veću stabilnost benzil izotiocijanata u želuĉanoj fazi u odnosu na crijevnu fazu probave i samim time veću biodostupnost ovog spoja u želucu.
Abstract (english)
Nasturtium (Tropaeolum majus L.) is an annual herbaceous plant, which is a rich source of vitamin C as well as other numerous biologically active compounds which are proved to have healing properties. It belongs to the small family Tropaeolaceae that belongs to the order Capparales. A particularly significant group of biologically active compounds that can be found in nasturtium are glucosinolates. They are chemically stable and biologically inactive compounds, while their degradation products can have various positive effects on the body. In this thesis essential oil isolated from nasturtium seeds by microwave extraction was analysed. The identification of compounds in the essential oil formed by glucosinolate hydrolysis was conducted using GC-MS technique. The results of this analysis showed the presence of two compounds, benzyl nitrile in small and benzyl isothiocyanate in the predominant amount. The aim was to examine the gastrointestinal stability of benzyl isothiocyanate in a simulated two-phase digestion model. The bioavailability of a compound indicates the amount of that compound that is released in the digestive tract and becomes available for absorption. Following an in vitro digestion model, analysis performed using GC-FID technique showed greater stability of benzyl isothiocyanate in the gastric phase relative to the intestinal digestion phase and, consequently, greater bioaccessibility of this compound in the stomach.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:166415
ProjectNumber: 1316
Title: Biljke kao izvor bioaktivnih sumporovih spojeva te njihova sposobnostt hiperakumulacije metala
Acronym: BioSMe
Leader: Ivica Blažević
Jurisdiction: Croatia
Funder: HRZZ
Study programmeTitle: Undergrasuate Study of Food Technology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni prvostupnik (baccalaureus) inženjer prehrambene tehnologije (sveučilišni prvostupnik (baccalaureus) inženjer prehrambene tehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2020-02-04 11:47:00