Cancer (lat. cancer) is the term used for a large group of diseases in which abnormal cells divide without control and are capable of penetrating and invadingother tissues. Clusters of abnormal cells may form benign or malignant tumors. The difference between them is in the growth aggressivness , and that the malignant tumors can metastasize and spread into the environment, penetrating into the surrounding tissue, while benign tumors do not give metastases to other organs and does not blend into the surrounding healthy tissue, they grow expansively. Phytotherapeutics or phytopharmaceuticals have active ingredients such as: plants, plant parts and their concotions, and include standardized herbal drugs with strictly defined content and a composition of a therapeutically active substance, which has confirmed the effectiveness of pharmacological and clinical research, with the indication of possible side effects and drug interactions. The main characteristic of phytopharmaceuticals / phytotherapeutics is the existence of a mixture of natural substances, and sometimes several plants (parts) are processed in a single concotion. The aim of this study was to examine the antiproliferative activity of aqueous extract of several Lamiaceae species, which can be found in Dalmatia, on breast cancer cells (MDA-MB 231) and prostate cancer (T24). The aqueous extract of Teucrium montanum L. showed the best anti-proliferative effect on cancer cells and prostate cancer. Extracts of plants of Satureja subspicata Bartl. ex Vis. and Melissa officinalis L. showed excellent activity in prostate cancer cells. In general, aqueous extracts of the Lamiaceae plant family exhibited better effect on the prostate cancer cells than on the breast cancer cells.