The chemistry of boron compounds is becoming increasingly investigated due to the specific properties of boron and its compounds that can be used in medicine and pharmacy. Boronic acids are chemical compounds containing a trivalent boron atom. Their mild reactivity and stability make boronic acids attractive as synthetic intermediates. Boron compounds possess significant biologically active properties that can be of exceptional benefit in the treatment of many diseases. The compound, 3- aminophenylboronic acid (3-APBA), exists as a white crystalline powder, soluble in water, methanol and dimethyl sulphoxide (DMSO). Another tested compound in this paper is called indomethacin. It is a substance in the form of a yellow crystalline powder, soluble in solvents such as chloroform, acetone, dimethyl sulphoxide (DMSO), etc. Indomethacin is a medicine that has anti-inflammatory, analgesic and antipyretic properties and belongs to a group of non-steroidal anti-inflammatory compounds. In this study, cytotoxic effect of a series of concentrations of 3-APBA and indomethacin on human fibroblasts and keratinocytes cells was tested. The MTT assay showed viability of cells, for both tested compunds in the concentration range of 0,012 mM to 0,391 mM. Concentration values which causes 50% inhibition of cell growth were calculated for each individual compound. All tested compounds showed higher toxicity to the keratinocyte cell line than to the fibroblasts cell line. The toxic effect of DMSO as solvent should also be taken into account. The highest toxicity was shown by indomethacin dissolved in DMSO, while the lowest toxicity was shown by 3-APBA dissolved in ultra-pure water.