Pharmacokinetics shows us fate of ingested drugs. The drug can be administered into the bloodstream intravenously, subcutaneously (under the skin), intramuscularly, rectally, topically (directly at the site where the action is expected), by inhalation and orally. The distribution in the organism is not uniform due to different blood supply to the organs, different composition and permeability of the membranes and different local pH. The liver is the most important organ in drug and xenobiotics (substances introduced into the body, foreign bodies) metabolism. The most important enzyme family in drug metabolism are cytochrome P450 enzymes (CYP 450). The kidneys are the most important organs for excretion of drugs from the body. Excretion is also possible by the liver in the bile. Nerolidol and farnesol are sesquiterpenic alcohols present in various floral fragrance of plants. They have numerous biological activities like anticancer activity. All programs and models for predicting biological activities could be divided into two groups: ligand (substrate) based and structural (enzyme) based. The site of metabolism (SOM) is a site in a molecule that consists of one or more atoms that interact with enzymes and change chemically. In this paper were used programs available on way2drug platform. SOMP (Site of Metabolism Prediction) was used to predict the site of organic matter metabolism for the five cytochrome P450 isoforms and the site for glucuronidation by UDP-glucuronyl transferase. RA (Reacting atom) was used for prediction of biotransformation sites, and the types of biotransformation reactions that could happen. The predictions obtained are not precise enough to show the metabolic pathways of nerolidol and farnesol in the body, but they provide a better view into the reactions that could take place and may help in further studies.