Clary sage (Salvia sclarea L.) is a plant from Lamiaceae family that naturally grows around the Mediterranean Sea, in southern Europe and northern Africa and in central Asia. The aim of this study was to determine the chemical profile of clary sage volatile compounds, from flowers and whole plant separately, and determine the composition and content of these compounds. For more complete insight into the composition and content of volatile compounds two isolation methods were used: hydrodistillation and headspace solid-phase microextraction (HS-SPME). Analysis of volatile samples was carried out by gas chromatography-mass spectrometry (GC/MS). Terpenes are qualitatively and quantitatively the most important ingredients of essential oils and headspaces obtained from clary sage flowers and whole plant. The major constituents of both essential oils, obtained from whole plant and from flowers, were oxygenated monoterpenes linalyl acetate (27,4-30,6%) and linalool (18,2-19,1%). The major constituents of headspaces were linalyl acetate (54,9%) and sesquiterpene germacrene D (19,7%) in sample obtained from whole plant, and linalyl acetate (76,6%) and linalool (6,1%) in sample obtained from flowers.