prikaz prve stranice dokumenta Citotoksični učinak Chelidonium majus, Alchemilla vulgaris i Polygonium aviculare na različite stanične linije humanih karcinoma
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master's thesis
Citotoksični učinak Chelidonium majus, Alchemilla vulgaris i Polygonium aviculare na različite stanične linije humanih karcinoma
diplomski rad
2016. urn:nbn:hr:167:784590
Mikić, Anni
University of Split
Faculty of Chemistry and Technology

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Mikić, A. (2016). Citotoksični učinak Chelidonium majus, Alchemilla vulgaris i Polygonium aviculare na različite stanične linije humanih karcinoma : diplomski rad (Master's thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:784590

Mikić, Anni. "Citotoksični učinak Chelidonium majus, Alchemilla vulgaris i Polygonium aviculare na različite stanične linije humanih karcinoma : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:167:784590

Mikić, Anni. "Citotoksični učinak Chelidonium majus, Alchemilla vulgaris i Polygonium aviculare na različite stanične linije humanih karcinoma : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:167:784590

Mikić, A. (2016). 'Citotoksični učinak Chelidonium majus, Alchemilla vulgaris i Polygonium aviculare na različite stanične linije humanih karcinoma : diplomski rad', Master's thesis, University of Split, Faculty of Chemistry and Technology, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:167:784590

Mikić A. Citotoksični učinak Chelidonium majus, Alchemilla vulgaris i Polygonium aviculare na različite stanične linije humanih karcinoma : diplomski rad [Master's thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2016 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:167:784590

A. Mikić, "Citotoksični učinak Chelidonium majus, Alchemilla vulgaris i Polygonium aviculare na različite stanične linije humanih karcinoma : diplomski rad", Master's thesis, University of Split, Faculty of Chemistry and Technology, Split, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:167:784590

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Metadata
TitleCitotoksični učinak Chelidonium majus, Alchemilla vulgaris i Polygonium aviculare na različite stanične linije humanih karcinoma : diplomski rad
Title (english)Cytotoxicity of Chelidonium majus, Alchemilla vulgaris and Polygonium aviculare on different cell lines of human cancers : master's thesis
AuthorAnni Mikić
MentorVedrana Čikeš Čulić (mentor)
Committee memberNatalija Filipović (predsjednik povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
Split
Defense date and country2016-10-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Abstract
Cilj istraţivanja bio je ispitati citotoksičnost vodenih ekstrakata biljaka Chelidonium majus (rosopas), Alchemilla vulgaris (vrkuta), Polygonum aviculare (troskot) na stanične linije humanih karcinoma mokraćnog mjehura (RT4, T24), dojke (MDA-MB-231), te pluća (A-549). Karcinomske stanice izloţene su različitim koncentracijama ekstrakata biljaka (0.1 g/, 0.25 g/L, 0.5 g/L i 1 g/L) i različitim vremenskim intervalima (4, 24, 48 i 72 sata). Postotak stanica koje su preţivjele ispitan je MTT-metodom. Dobiveni rezultati pokazali su da vodeni ekstrakti rosopasa, vrkute i troskota pokazuju citotoksični učinak na stanične linije karcinoma mokraćnog mjehura, dojke i pluća jer smanjuju broj ţivih stanica. Citotoksičnost ekstrakata biljaka ovisila je o vremenu u kojem je odreĎena stanična linija bila izloţena ekstraktu, te o koncentraciji biljnih ekstrakata, a smanjenje preţivljenja nije nuţno bilo proporcionalno povećanju koncentracije ekstrakata biljaka.
Abstract (english)
The aim of this study was to examine the cytotoxicity of aqueous extracts of plants Chelidonium majus (greater celandine), Alchemilla vulgaris (lady’s mantle), Polygonum aviculare (knotweed) on cell lines of human bladder cancer (RT4, T24), breast cancer (MDA-MB-231), and lung cancer (A-549). Cancer cells were exposed to various concentrations of plant extracts (0.1 g/L, 0.25 g/L, 0.5 g/L and 1 g/L) and different time intervals (4, 24, 48 and 72 hours). The percentage of cells that survived was tested by the MTT method. The results showed that aqueous extracts greater celandine, lady’s mantle and knotweed show cytotoxic effects on cell lines of bladder, breast and lung cancer as they reduce the number of viable cells. The cytotoxicity of plant extracts depended on the time in which a particular cell line was exposed to the extract, and the concentration of plant extracts and reducing survival was not necessarily proportional to the increase in the concentration of plant extracts.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:784590
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-11-23 12:10:37