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undergraduate thesis
Inhibicija acetilkolinesteraze odabranim organskim sulfidima
završni rad
2019. urn:nbn:hr:167:269497
Pedić, Katarina
University of Split
Faculty of Chemistry and Technology
Division of Chemistry

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Pedić, K. (2019). Inhibicija acetilkolinesteraze odabranim organskim sulfidima : završni rad (Undergraduate thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:269497

Pedić, Katarina. "Inhibicija acetilkolinesteraze odabranim organskim sulfidima : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:167:269497

Pedić, Katarina. "Inhibicija acetilkolinesteraze odabranim organskim sulfidima : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:167:269497

Pedić, K. (2019). 'Inhibicija acetilkolinesteraze odabranim organskim sulfidima : završni rad', Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, accessed 03 April 2025, https://urn.nsk.hr/urn:nbn:hr:167:269497

Pedić K. Inhibicija acetilkolinesteraze odabranim organskim sulfidima : završni rad [Undergraduate thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2019 [cited 2025 April 03] Available at: https://urn.nsk.hr/urn:nbn:hr:167:269497

K. Pedić, "Inhibicija acetilkolinesteraze odabranim organskim sulfidima : završni rad", Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:167:269497

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Metadata
TitleInhibicija acetilkolinesteraze odabranim organskim sulfidima : završni rad
Title (english)Acetylcholinesterase inhibition with selected organic sulfides : bachelor thesis
AuthorKatarina Pedić
MentorFranko Burčul (mentor)
MBZ: 308276
Committee memberIvica Blažević (predsjednik povjerenstva)
Committee memberMario Nikola Mužek (član povjerenstva)
Committee memberFranko Burčul (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
Defense date and country2019-07-11, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Enzimi su snažni biokatalizatori bez čije se aktivnosti većina kemijskih reakcija u biološkom sustavu ne bi odvijala. Enzimskoj skupini hidrolaza pripada jedan od najučinkovitijih enzima u prirodi, acetilkolinesteraza (AChE). Fiziološka uloga AChE je da prilikom prijenosa živčanog impulsa hidrolizira neuroprijenosnik acetilkolin (ACh) na acetat i kolin i tako smanjuje aktivnost ACh. Važan je faktor u tretmanu teških neurodegenerativnih bolesti poput Alzheimerove bolesti. ... More Alzheimerova bolest (AD) predstavlja najučestaliji tip demencije u suvremenom svijetu. AD je neizlječiva bolest živčanih stanica (neurona) i okolnih struktrura sa smrtnim ishodom. Inhibitorima kolinesteraza, uz ostale proučavane metode, nastoje se ublažiti simptomi ove progresivne bolesti, a krajnji cilj je pronaći lijek. Cilj rada bio je ispitati inhibicijsko djelovanje odabranih organskih sulfida (inhibitora) na enzim acetilkolinesterazu metodom po Ellmanu. Ellmanova metoda zasniva se na reakciji Ellmanovog reagensa i tiolne skupine pri čemu nastaje žuto obojeni kompleks. Od odabranih sulfida najveću inhibicijsku sposobnost pokazao je dimetil-trisulfid pri koncentraciji od 568 μM, a iznosi 40,23 %. Smanjenjem koncentracije inhibitora smanjuje se i njegov učinak. Uzorak koji jedini nije pokazao inhibicijsko djelovanje pri različitim koncentracijama je dipropil-trisulfid. Less
Abstract (english)
Enzymes are powerful biocatalysts without which the majority of chemical reactions in the biological system would not occur. One of the most effective enzymes in nature, acetylcholinesterase (AChE) belongs to the enzyme group of hydrolases. The physiological role of AChE is to hydrolyse the neurotransmitter acetylcholine (ACh) after transmission of a nervous pulse to acetate and choline and thus reduce its activity. It is an important factor in the... More treatment of severe neurodegenerative diseases such as Alzheimer's disease. Alzheimer's Disease (AD) is the most common type of dementia in the modern world. AD is an incurable disease of nerve cells (neurons) and surrounding structures with a deadly outcome. Cholinesterase inhibitors, along with the other studied methods, are used to alleviate the symptoms of this progressive disease, and the ultimate goal is to find a cure. The aim of the study was to investigate the inhibitory effect of selected organic sulfides (inhibitors) on the enzyme acetylcholinesterase using Ellman’s method. Ellman's method is based on the reaction of Ellman's reagent and the thiol groups yielding a yellow coloured complex. Between the selected sulfides dimethyl trisulfide showed the highest inhibition capability of 40.23% at a concentration of 568 μM. Reduction of the concentration of the inhibitor decreased the inhibitory effect. Dipropyl trisulfide was the only sulfide that did not show any inhibitory activity at tested concentrations. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:269497
ProjectNumber: 1316
Title: Biljke kao izvor bioaktivnih sumporovih spojeva te njihova sposobnost hiperakumulacije metala
Acronym: BioSMe
Leader: Ivica Blažević
Jurisdiction: Croatia
Funder: HRZZ
Study programmeTitle: Chemical Technology; specializations in: Chemical Engineering, Environmental Protection
Course: Chemical Engineering
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Public noteKljučne riječi doradio knjižničar/ Key words are revised by the librarian
Created on2019-10-02 09:31:23
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