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master's thesis
Sinteza i kemijska modifikacija derivata 2-(3-nitrobenzilidena) amino-1H-benzimidazola i njihova antibakterijska aktivnost
diplomski rad
2018. urn:nbn:hr:167:187450
Kvesić, Marija
University of Split
Faculty of Chemistry and Technology

Cite this document

Kvesić, M. (2018). Sinteza i kemijska modifikacija derivata 2-(3-nitrobenzilidena) amino-1H-benzimidazola i njihova antibakterijska aktivnost : diplomski rad (Master's thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:187450

Kvesić, Marija. "Sinteza i kemijska modifikacija derivata 2-(3-nitrobenzilidena) amino-1H-benzimidazola i njihova antibakterijska aktivnost : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:167:187450

Kvesić, Marija. "Sinteza i kemijska modifikacija derivata 2-(3-nitrobenzilidena) amino-1H-benzimidazola i njihova antibakterijska aktivnost : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2018. https://urn.nsk.hr/urn:nbn:hr:167:187450

Kvesić, M. (2018). 'Sinteza i kemijska modifikacija derivata 2-(3-nitrobenzilidena) amino-1H-benzimidazola i njihova antibakterijska aktivnost : diplomski rad', Master's thesis, University of Split, Faculty of Chemistry and Technology, accessed 16 November 2024, https://urn.nsk.hr/urn:nbn:hr:167:187450

Kvesić M. Sinteza i kemijska modifikacija derivata 2-(3-nitrobenzilidena) amino-1H-benzimidazola i njihova antibakterijska aktivnost : diplomski rad [Master's thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2018 [cited 2024 November 16] Available at: https://urn.nsk.hr/urn:nbn:hr:167:187450

M. Kvesić, "Sinteza i kemijska modifikacija derivata 2-(3-nitrobenzilidena) amino-1H-benzimidazola i njihova antibakterijska aktivnost : diplomski rad", Master's thesis, University of Split, Faculty of Chemistry and Technology, Split, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:167:187450

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Metadata
TitleSinteza i kemijska modifikacija derivata 2-(3-nitrobenzilidena) amino-1H-benzimidazola i njihova antibakterijska aktivnost : diplomski rad
Title (english)Synthesis and chemical modification of 2-(3-nitrobenzylidene) amino-1H-benzimidazole derivatives and their antibacterial activity : diploma thesis
AuthorMarija Kvesić
MentorIvica Blažević (mentor)
MBZ: 267194
Committee memberAni Radonić (predsjednik povjerenstva)
Committee memberFranko Burčul (član povjerenstva)
Committee memberIvica Blažević (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
Split
Defense date and country2018-10-11, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
2-Amino-1H-benzimidazol zahvaljući svom širokom spektru biološke aktivnosti prema različitim oboljenjima, dio je strukture velikog broja lijekova (Bezitramid, Dibazol, Mebendazol…). Iako je nekoliko metoda sinteze 2-amino-1H- benzimidazola već poznato, pronalazak novih metoda sinteze bio bi od velike važnosti za otkriće novih lijekova. Obzirom da je navedeni spoj potencijalno dobar kemoterapeutik, zanimljiv je i za organsku i medicinsku kemiju. Kondezacijom Schiffove baze s odabranim sekundarnim i primarnim aminima, nitrilima i diketonima, koji u svojoj strukturi sadrže aktivne metilenske skupine, dobiveni su različiti derivati spoja 2-(3-nitrobenziliden)amino-1H-benzimidazola. U svrhu praćenja sinteze korištena je tankoslojna kromatografija (TLC). Sintetizirani spojevi potvrđeni su 1 H NMR i IR spektroskopijom kao i elementnom analizom. Svi dobiveni spojevi podvrgnuti su daljnjim ispitivanjima antibakterijske aktivnosti na Gram-pozitivni bakterijski soj (Staphylococcus aureus) i Gram-negativne bakterijske sojeve (Escherichia coli i Pseudomonas aeruginosa). Dobiveni rezultati bioloških testova omogućit će određivanje odnosa između strukture i biološke aktivnosti (SAR).
Abstract (english)
2-Amino-1H-benzimidazole thanks to its wide range of biological activity against various illnesses is part of the structure of a large number of drugs (Bezitramid, Dibazol, Mebendazol ...). Although several methods of synthesis of 2-amino- 1H-benzimidazole are already known, finding of new synthetic methods would be of great importance for the discovery of new drugs. Considering that mentioned compound has potentially good chemotherapeutic characteristics, it is interesting to organic and medical chemistry. By condensing the Schiff base with the selected secondary and primary amines, nitriles and diketones, which contain active methylene groups in its structure, various derivatives of 2- (3-nitrobenzylidene) amino-1H-benzimidazole are obtained. Thin layer chromatography (TLC) was used to monitor the synthesis. The synthesized compounds were confirmed by 1 H NMR and IR spectroscopy as well as elemental analysis. All the obtained compounds are tested for the antibacterial activity on Gram positive bacterial strain (Staphylococcus aureus) and Gram negative bacterial strains (Escherichia coli i Pseudomonas aeruginosa). The obtained biological test results will allow the determination of the relationship between structure and biological activity (SAR).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:187450
Study programmeTitle: Chemistry; specializations in: Environmental Protection, Organic Chemistry and Biochemistry
Course: Environmental Protection
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Public noteKljučne riječi doradio knjižničar/ Key words are revised by the librarian
Created on2019-04-02 12:24:02