Green solvents are ecologically safe solvents with high safety profile and low potential for incidents. They have a large importance in green chemistry whose framework is made up of 12 principles which have a goal to improve classic chemical synthesis, production processes and lower the damaging effect on the environment. Classical solvents like chlorinated hydrocarbons and unsaturated aromatic compounds are the biggest problem in the pharmaceutical industry because they are used in large quantities which very negatively affect the green chemistry metrics (i.e E factor, process mass intensity, atom economy). Examples of green solvents are: water, glycerol, ethyl lactate, supercritical carbon dioxide, certain ionic liquids. The objective of this thesis was to study the available professional and scientific literature and find the examples of green solvents use in pharmaceutical industry. The syntheses of following active pharmaceutical ingredients have been studied: sildenafil, pregabalin, sertraline, 7-aminocephalosporanic acid, celecoxib, quinapril, sitagliptin. The synthesis has been compared before and after implementation of green chemistry principles including the use of green solvents. After the implementation of green chemistry in all examples the significant improvement in ecological and safety profile of the reaction has been accomplished. Also, the changes in synthesis of the mentioned active pharmaceutical ingredients have left very positive results on the green chemistry metrics. Green chemistry and green solvents have brought large changes in the pharmaceutical industry and have significantly contributed to ecology and nature preservation while also improving the safety of workers in pharmaceutical factories. Despite the positive changes, there is still plenty of space left for improvement which should further encourage research of green chemistry.