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master's thesis
Pronalaženje dokaza o djelotvornosti i sigurnosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva (IBS): sustavni pregled literature
diplomski rad
2017. urn:nbn:hr:167:421651
Bućan, Marija
University of Split
Faculty of Chemistry and Technology
Division of Chemistry
University of Split
School of Medicine

Cite this document

Bućan, M. (2017). Pronalaženje dokaza o djelotvornosti i sigurnosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva (IBS): sustavni pregled literature : diplomski rad (Master's thesis). Split: University of Split, Faculty of Chemistry and Technology; Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:421651

Bućan, Marija. "Pronalaženje dokaza o djelotvornosti i sigurnosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva (IBS): sustavni pregled literature : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology; University of Split, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:167:421651

Bućan, Marija. "Pronalaženje dokaza o djelotvornosti i sigurnosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva (IBS): sustavni pregled literature : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology; University of Split, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:167:421651

Bućan, M. (2017). 'Pronalaženje dokaza o djelotvornosti i sigurnosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva (IBS): sustavni pregled literature : diplomski rad', Master's thesis, University of Split, Faculty of Chemistry and Technology; University of Split, School of Medicine, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:167:421651

Bućan M. Pronalaženje dokaza o djelotvornosti i sigurnosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva (IBS): sustavni pregled literature : diplomski rad [Master's thesis]. Split: University of Split, Faculty of Chemistry and Technology; Split: University of Split, School of Medicine; 2017 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:167:421651

M. Bućan, "Pronalaženje dokaza o djelotvornosti i sigurnosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva (IBS): sustavni pregled literature : diplomski rad", Master's thesis, University of Split, Faculty of Chemistry and Technology, Split; University of Split, School of Medicine, Split, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:167:421651

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Metadata
TitlePronalaženje dokaza o djelotvornosti i sigurnosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva (IBS): sustavni pregled literature : diplomski rad
Title (english)Finding evidence of efficacy and safety of homeopathy for treatment of irritabile bowel syndrome: systematic review approach : diploma thesis
AuthorMarija Bućan
MentorDarko Modun (mentor)
Committee memberRenata Pecotić (predsjednik povjerenstva)
Committee memberZoran Valić (član povjerenstva)
Committee memberDarko Modun (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
GranterUniversity of Split
School of Medicine
Split
Defense date and country2017-10-05, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Abstract
Cilj istraživanja: Pronaći najbolje dostupne dokaze o sigurnosti i učinkovitosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva. Materijal i metode: Temelj istraživanja predstavlja sustavni pregled „Homeopathy for treatment of irritable bowel syndrome“ pronađen na stranici Cochrane Library. Pretraživanjem baza MEDLINE, DARE i CENTRAL pronađen je jedan randomizirani kontrolirani pokus, na temelju ulaznih i izlaznih kriterija Cochrane sustavnog pregleda. Procjena kvalitete Cochrane sustavnog pregleda učinjena je koristeći R-AMSTAR kriterije. Rezultati: Osim Cochrane sustavnog pregleda pronađen je jedan randomizirani kontrolirani pokus. Cochrane sustavni pregled uključio je tri randomizirana kontrolirana pokusa. Meta-analiza dvaju randomiziranih kontroliranih pokusa obrađenih u Cochrane sustavnom pregledu pronašla je statistički značajnu razliku u sveukupnom poboljšanju zdravlja između homeopatskog pripravka i placeba, u korist homeopatskog pripravka. Treća studija uključena u Cochrane sustavni pregled nije pronašla statistički značajnu razliku između homeopatskog i uobičajenog liječenja. Randomizirani kontrolirani pokus pronađen nakon zadnjeg pregleda literature Cochrane sustavnog pregleda pokazao je statistički značajnu razliku u koristi homeopatskog liječenja, prilikom uspoređivanja poboljšanja skupine liječene samo uobičajenim liječenjem i skupine liječene homeopatijom uz uobičajeno liječenje. Cochrane sustavni pregled ocijenjen je s ukupno 38 bodova. Zaključak: Dokazi o djelotvornosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva su ograničeni te ih treba tumačiti s oprezom zbog upitne metodološke kvalitete ispitivanja, kratkog trajanja studija, malog broja ispitanika te nedostatka podataka. Zbog svega navedenog ne može se dati pouzdan zaključak o djelotvornosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva. Nijedna od uključenih studija nije izvjestila o nuspojavama homeopatskih pripravaka, stoga ne može se donijeti zaključak o sigurnosti homeopatskih pripravaka u liječenju sindroma iritabilnog crijeva.
Abstract (english)
Objectives: : Finding the best available evidence of efficacy and safety of homeopathy for treatment of irritable bowel syndrome Material and methods: The basis of the research is the systematic review „Homeopathy for treatment of irritable bowel syndrome“ found on Cochrane Library website. New randomised controlled trial was found by searching MEDLINE, DARE and CENTRAL databases, following the inclusion and exclusion criteria used in Cochrane systematic review. Quality assessment of Cochrane systematic review was made using R-AMSTAR tool. Results: Beside Cochrane systematic review one randomised controlled trial was found. Cochrane systematic review included three randomised controlled trials. A meta-analysis of two studies found a statistically significant difference in global improvement in the homeopathy group and placebo, in favour of homeopathic treatment. Third study included in Cochrane systematic review found no statistically significant difference between individualsed homeopatic treatment and usual care. Randomised controlled trial found after the last Cochranes literature search found statistically significant difference between homeo- pathic treatment plus usual care and usual care alone, in favour of homeopathic treatment. R-AMSTAR total score for Cochrane systematic review was 38 points. Conclusion: Clinical evidence in support of efficacy of homeopathy in treatment of irritable bowel syndrome are limited and should be interpreted with caution due to the questionable methodological quality of trials, short- term follow-up, small number of participants, and sparse dana, therefore no conclusion about efficacy of homeopathy in treatment of irritable bowel syndrome can be drawn. None of the included studies reported about side effects of homeopathic remedies so conclusion about safety of homeopathy cannot be made.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:421651
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Public noteKljučne riječi doradio knjižničar/ Key words are revised by the librarian
Created on2018-06-26 10:00:51