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undergraduate thesis
Teranostički potencijal nesimetrično supstituiranog amidnog difenilantracenskog derivata kaliks[4]arena
završni rad
2022. urn:nbn:hr:167:549380
Bošnjak, Julijana
University of Split
Faculty of Chemistry and Technology
Division of Chemistry

Cite this document

Bošnjak, J. (2022). Teranostički potencijal nesimetrično supstituiranog amidnog difenilantracenskog derivata kaliks[4]arena : završni rad (Undergraduate thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:549380

Bošnjak, Julijana. "Teranostički potencijal nesimetrično supstituiranog amidnog difenilantracenskog derivata kaliks[4]arena : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:167:549380

Bošnjak, Julijana. "Teranostički potencijal nesimetrično supstituiranog amidnog difenilantracenskog derivata kaliks[4]arena : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:167:549380

Bošnjak, J. (2022). 'Teranostički potencijal nesimetrično supstituiranog amidnog difenilantracenskog derivata kaliks[4]arena : završni rad', Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, accessed 11 December 2024, https://urn.nsk.hr/urn:nbn:hr:167:549380

Bošnjak J. Teranostički potencijal nesimetrično supstituiranog amidnog difenilantracenskog derivata kaliks[4]arena : završni rad [Undergraduate thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2022 [cited 2024 December 11] Available at: https://urn.nsk.hr/urn:nbn:hr:167:549380

J. Bošnjak, "Teranostički potencijal nesimetrično supstituiranog amidnog difenilantracenskog derivata kaliks[4]arena : završni rad", Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:167:549380

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Metadata
TitleTeranostički potencijal nesimetrično supstituiranog amidnog difenilantracenskog derivata kaliks[4]arena : završni rad
Title (english)Calixarene derivatives in theranostics : bachelor thesis
AuthorJulijana Bošnjak
MentorMarina Tranfić Bakić (mentor)
Committee memberMila Radan (predsjednik povjerenstva)
Committee memberAnte Prkić (član povjerenstva)
Committee memberMarina Tranfić Bakić (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
Defense date and country2022-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
S ciljem da se ispita kompleksacijski afinitet nesimetrično supstrituiranog amidnog difenilantracenskog derivata kaliksarena 5,11,17,23-tetra-tert-butil-25-(9,10-difenilantracen-2-iloksietoksi)- 26,27,28-tris(N,N-dietil-karbamoilmetoksi)kaliks[4]arena, L, prema organskim bojama - rodaminu B, auraminu O i fluoresceinu te aktivnoj tvari – timokinonu, proveden je niz spektrofotometrijskih titracija u acetonitrilu. Određene su i konstante stabilnosti odgovarajuć ih kompleksa koje ukazuju na nastanak relativno stabilnih kompleksa derivata kaliks[4]arena L s istraživanim bojama, pri čemu je spoj L pokazao najveći afinitet prema auraminu O. S druge strane, s timokinonom nije došlo do vezanja zbog njegove strukturne nekomplementarnosti s veznim mjestom liganda. Iako kompleksu [L- fluorescein] nije bilo moguće odrediti konstantu stabilnosti, iz eksperimentalnih je podataka bio vidljiv nastanak kompleksa, te je njena vrijednost procijenjena kao niža u odnosu na odgovarajuće konstante za rodamin B i auramin O. Ispitani derivat kaliksarena demonstrirao je dobre receptorske sposobnosti veznog mjesta koje se sastoji od tercijarnih amidnih skupina i difenilantracenske skupine, pa je za očekivati da bi njegov vodotopivi analog imao velik potencijal u teranostici.
Abstract (english)
In order to investigate the complexation affinity of the asymmetrically substituted amide diphenylanthracene derivative of calixarene 5,11,17,23-tetra-tert-butyl-25-(9,10-diphenylanthracene-2- yloxyethoxy)-26,27,28-tris(N,N-diethyl-carbamoylmethoxy) calix[4]arene, L, towards the organic dyes – rhodamine B, auramine O and fluorescein and the active compound – thymoquinone, a series of spectrophotometric titrations in acetonitrile were carried out. The stability constants of the corresponding complexes were determined and their values indicated that relatively stable complexes of calix[4]arene derivatives L with the studied dyes were formed, with compound L showing the highest affinity for the binding of auramine O. On the other hand, the complex with thymoquinone did not form under the experimental conditions used, due to its structural incompatibility with the ligand's binding site. Although the value of the stability constant for [L-fluorescein] complex could not be determined, there was experimental evidence of the complex formation and its value was estimated to be lower than the corresponding constants for rhodamine B and auramine O. Since the studied calixarene derivative demonstrated good receptor properties of the binding site composed of tertiary amide groups and a diphenylanthracene group, it can be expected that its water-soluble analogue should have great potential for applications in theranostics.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:549380
Study programmeTitle: Food technology - undergraduate - university
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/ baccalaurea) inženjer/ inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/ baccalaurea) inženjer/ inženjerka prehrambene tehnologije)
Type of resourceText
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Created on2023-03-31 09:16:44