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undergraduate thesis
Disupstituitani fenantridinski derivat kaliks[4]arena za primjenu u teranostici
završni rad
2022. urn:nbn:hr:167:766319
Galić, Jelena
University of Split
Faculty of Chemistry and Technology
Division of Chemistry

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Galić, J. (2022). Disupstituitani fenantridinski derivat kaliks[4]arena za primjenu u teranostici : završni rad (Undergraduate thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:766319

Galić, Jelena. "Disupstituitani fenantridinski derivat kaliks[4]arena za primjenu u teranostici : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:167:766319

Galić, Jelena. "Disupstituitani fenantridinski derivat kaliks[4]arena za primjenu u teranostici : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:167:766319

Galić, J. (2022). 'Disupstituitani fenantridinski derivat kaliks[4]arena za primjenu u teranostici : završni rad', Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, accessed 16 November 2024, https://urn.nsk.hr/urn:nbn:hr:167:766319

Galić J. Disupstituitani fenantridinski derivat kaliks[4]arena za primjenu u teranostici : završni rad [Undergraduate thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2022 [cited 2024 November 16] Available at: https://urn.nsk.hr/urn:nbn:hr:167:766319

J. Galić, "Disupstituitani fenantridinski derivat kaliks[4]arena za primjenu u teranostici : završni rad", Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:167:766319

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Metadata
TitleDisupstituitani fenantridinski derivat kaliks[4]arena za primjenu u teranostici : završni rad
Title (english)Disubstituted phenanthridine derivative of calix[4]arene for application in theranostic : bachelor thesis
AuthorJelena Galić
MentorMarina Tranfić Bakić (mentor)
Committee memberMila Radan (predsjednik povjerenstva)
Committee memberMaša Buljac (član povjerenstva)
Committee memberMarina Tranfić Bakić (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
Defense date and country2022-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Spektrofotometrijskim titracijama ispitano je kompleksiranje fluorescentnih boja rodamina B, auramina O i fluoresceina, te antitumorskog lijeka timokinona s disupstituiranim fenantridinskim derivatom kaliks[4]arena, 5,11,17,23-tetra-tert-butil-25,27-(bis(6-fenantridinilmetoksi)-26,28- dihidroksikaliks[4]arenom (L), u sustavu otapala acetonitril/diklormetan pri sobnoj temperaturi. Obradom eksperimentalnih podataka određene su konstante stabilnosti kompleksa spoja L s rodaminom B i auraminom O, dok konstantu stabilnosti kompleksa spoja L s fluoresceinom nije bilo moguće odrediti iako je vidljivo nastajanje kompleksa. Spoj L nije vezao antitumorski lijek timokinon u eksperimentalnim uvjetima korištenim u okviru ovog završnog rada. Usporedbom vrijednosti konstanti stabilnosti kompleksa spoja L s rodaminom B i auraminom O, vidljivo je da spoj L pokazuje podjednak afinitet prema vezanju obje boje i tvori s njima poprilično stabilne komplekse. Dobiveni eksperimentalni podaci upućuju na zaključak da fenantridinske podjedinice na donjem obodu kaliksarenskog derivata L pružaju dobro vezno mjesto za istraživane boje , te bi stoga ovaj derivat mogao imati velik potencijal za primjenu u teranostici, ukoliko bi se supstitucijom na gornjem obodu osigurala njegova vodotopljivost.
Abstract (english)
Complexation of fluorescent dyes rhodamine B, auramine O, and fluorescein, as well as the antitumor drug thymoquinone with disubstituted phenanthridine derivative of calix[4]arene, 5,11,17,23- tetra-tert-butyl-25,27-(bis(6-phenanthridinemethoxy)-26,28-dihydroxycalix[4]arene (L), was studeied by means of spectrophotometric titrations in the solvent system acetonitrile/dichloromethane, at room temperature. By processing the experimental data, the stability constants of the complexes of compound L with rhodamine B and auramine O were determined, while the stability constant of the complex of compound L with fluorescein could not be determined, although the formation of the complex was noted. Compound L did not bind the antitumor drug thymoquinone under the experimental conditions used in this bachelor thesis. Comparison of the values of the stability constants of the complexes of compound L with rhodamine B and auramine O, showed that compound L exibits equal affinity for the binding of both dyes and forms fairly stable complexes with them. The obtained experimental data lead to the conclusion that phenanthridine subunits on the endo rim of the calixarene derivative L provide a good binding site for the tested dyes, and therefore this derivative, modified at the exo rim with substituents that would ensure its solubility in water, could have great potential for application in theranostics.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:766319
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2023-02-08 11:42:10