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master's thesis
Mehanokemijska sinteza kokristala hidroksibenzojevih kiselina i uree u čvrstom stanju
diplomski rad
2021. urn:nbn:hr:167:353519
Lukin, Anđela
University of Split
Faculty of Chemistry and Technology
Division of Chemistry

Cite this document

Lukin, A. (2021). Mehanokemijska sinteza kokristala hidroksibenzojevih kiselina i uree u čvrstom stanju : diplomski rad (Master's thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:353519

Lukin, Anđela. "Mehanokemijska sinteza kokristala hidroksibenzojevih kiselina i uree u čvrstom stanju : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:167:353519

Lukin, Anđela. "Mehanokemijska sinteza kokristala hidroksibenzojevih kiselina i uree u čvrstom stanju : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2021. https://urn.nsk.hr/urn:nbn:hr:167:353519

Lukin, A. (2021). 'Mehanokemijska sinteza kokristala hidroksibenzojevih kiselina i uree u čvrstom stanju : diplomski rad', Master's thesis, University of Split, Faculty of Chemistry and Technology, accessed 18 April 2024, https://urn.nsk.hr/urn:nbn:hr:167:353519

Lukin A. Mehanokemijska sinteza kokristala hidroksibenzojevih kiselina i uree u čvrstom stanju : diplomski rad [Master's thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2021 [cited 2024 April 18] Available at: https://urn.nsk.hr/urn:nbn:hr:167:353519

A. Lukin, "Mehanokemijska sinteza kokristala hidroksibenzojevih kiselina i uree u čvrstom stanju : diplomski rad", Master's thesis, University of Split, Faculty of Chemistry and Technology, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:167:353519

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Metadata
TitleMehanokemijska sinteza kokristala hidroksibenzojevih kiselina i uree u čvrstom stanju : diplomski rad
Title (english)Mechanochemical synthesis of cocrystals between hydroxybenzoic acids and urea in the solid state : diploma thesis
AuthorAnđela Lukin
MentorVesna Sokol (mentor)
Committee memberBoris-Marko Kukovec (predsjednik povjerenstva)
Committee memberIvana Škugor Rončević (član povjerenstva)
Committee memberVesna Sokol (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U radu je opisana priprema kokristala hidroksibenzojevih kiselina (orto-, meta-, para-) i uree mehanokemijskom sintezom u čvrstom stanju. Kokristali su pripremljeni reakcijama suhog mljevenja i tekućinski potpomognutog mljevenja koristeći mikrolitarske količine etanola ili nitrometana. Reakcije su praćene Ramanovom spektroskopijom in situ kojom iz dobivenih vremenski ovisnih 2D Ramanskih spektara možemo dobiti uvid u kinetiku formiranja pojedinog kokristala pri određenim reakcijskim uvjetima. Kokristali meta- ili para- hidroksibenzojeve kiseline i uree, čije strukture do sad nisu bile poznate, određeni su pomoću difrakcije rendgenskim zračenjem na prahu i monokristalu. Kompeticijskim reakcijama s po dvije kiseline koje mogu tvoriti kokristal s ureom određen je odnos termodinamičke stabilnosti između sva tri kokristala. U uvjetima suhog i tekućinski potpomognutog mljevenja uvijek je preferiran nastanak kokristala s p-hidroksibenzojevom kiselinom, dok kokristal s m-hidroksibenzojevom kiselinom ni u jednom slučaju nije preferencijalno nastao te se time zaključuje kako je taj kokristal najmanje stabilan.
Abstract (english)
In this thesis, we describe the formation of cocrystals of hydroxybenzoic acids (ortho-, meta-, para-) and urea by mechanochemical synthesis in the solid state. The cocrystals were formed by neat grinding and liquid assisted grinding (LAG) reactions using microliters amounts of ethanol or nitromethane. Reactions were monitored by Raman spectroscopy in situ resulting in time-dependent Raman spectra from which we can gain insight into the kinetics of cocrystal formation. The synthesized cocrystals of meta- and para-hydroxybenzoic acid and urea, whose structures were unknown, were identified by X-ray diffraction on powder and single crystal. The relationship of thermodynamic stability between these three cocrystals was determined by competition reactions between two possible hydroxybenzoic acid coformers. Under neat and LAG milling conditions, the formation of a cocrystal with p-hydroxybenzoic acid is always favored, while a cocrystal with m-hydroxybenzoic acid is not preferentially formed in any system, thus concluding that it is the least stable cocrystal.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:353519
Study programmeTitle: Chemistry; specializations in: Environmental Protection, Organic Chemistry and Biochemistry
Course: Environmental Protection
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-01-14 10:29:43